|
KMID : 1161420140170101049
|
|
Journal of Medicinal Food
2014 Volume.17 No. 10 p.1049 ~ p.1056
|
|
|
Rubus coreanus Miquel Ameliorates Scopolamine-Induced Memory Impairments in ICR Mice
|
|
Choi Mi-Ran
Lee Min-Young
Hong Ji-Eun
Kim Jeong-Eun
Lee Jae-Yong
Kim Tae-Hwan
Chun Jang-Woo
Shin Hyun-Kyung
Kim Eun-Ji
|
|
|
Abstract
|
|
|
|
The present study investigated the effect of Rubus coreanus Miquel (RCM) on scopolamine-induced memory impairments in ICR mice. Mice were orally administrated RCM for 4 weeks and scopolamine was intraperitoneally injected into mice to induce memory impairment. RCM improved the scopolamine-induced memory impairment in mice. The increase of acetylcholinesterase activity caused by scopolamine was significantly attenuated by RCM treatment. RCM increased the levels of acetylcholine in the brain and serum of mice. The expression of choline acetyltransferase, phospho-cyclic AMP response element-binding protein, and phospho-extracellular signal-regulated kinase was significantly increased within the brain of mice treated with RCM. The brain antioxidant enzyme activity decreased by scopolamine was increased by RCM. These results demonstrate that RCM exerts a memory-enhancing effect via the improvement of cholinergic function and the potentiated antioxidant activity in memory-impaired mice. The results suggest that RCM may be a useful agent for improving memory impairment.
|
|
|
KEYWORD
|
|
|
acetylcholinesterase, memory impairment, Rubus coreanus Miquel, scopolamine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|